Look to the main chance.

Keep your attention on the opportunity most likely to benefit you. The proverb urges practical awareness of where a worthwhile gain may lie.

It can also suggest self-interest: someone who looks to the main chance may put personal advantage ahead of loyalty, generosity, or a less profitable course.

Use it to urge someone not to lose sight of a promising opportunity when making a decision. It can also describe a person whose choices seem guided chiefly by what they stand to gain.